Ontology highlight
ABSTRACT:
SUBMITTER: John SP
PROVIDER: S-EPMC6492923 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
John Sinu P SP Sun Jing J Carlson Rebecca J RJ Cao Binh B Bradfield Clinton J CJ Song Jian J Smelkinson Margery M Fraser Iain D C IDC
Cell reports 20181001 1
Activation of the TLR4 signaling pathway by lipopolysaccharide (LPS) leads to induction of both inflammatory and interferon-stimulated genes, but the mechanisms through which these coordinately activated transcriptional programs are balanced to promote an optimal innate immune response remain poorly understood. In a genome-wide small interfering RNA (siRNA) screen of the LPS-induced tumor necrosis factor α (TNF-α) response in macrophages, we identify the interferon-stimulated protein IFIT1 as a ...[more]