Ontology highlight
ABSTRACT:
SUBMITTER: Chandler M
PROVIDER: S-EPMC6493337 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Nature reviews. Microbiology 20130708 8
HUH endonucleases are numerous and widespread in all three domains of life. The major function of these enzymes is processing a range of mobile genetic elements by catalysing cleavage and rejoining of single-stranded DNA using an active-site Tyr residue to make a transient 5'-phosphotyrosine bond with the DNA substrate. These enzymes have a key role in rolling-circle replication of plasmids and bacteriophages, in plasmid transfer, in the replication of several eukaryotic viruses and in various t ...[more]