Ontology highlight
ABSTRACT:
SUBMITTER: Boyapati RK
PROVIDER: S-EPMC6494506 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Boyapati Ray K RK Torres Joana J Palmela Carolina C Parker Claire E CE Silverberg Orli M OM Upadhyaya Sonam D SD Nguyen Tran M TM Colombel Jean-Frédéric JF
The Cochrane database of systematic reviews 20180512
<h4>Background</h4>Crohn's disease (CD) is a chronic, relapsing and remitting disease of the gastrointestinal tract that can cause significant morbidity and disability. Current treatment guidelines recommend early intervention with immunosuppressant or biological therapy in high-risk patients with a severe disease phenotype at presentation. The feasibility of therapeutic de-escalation once remission is achieved is a commonly encountered question in clinical practice, driven by patient and clinic ...[more]