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Withdrawal of immunosuppressant or biologic therapy for patients with quiescent Crohn's disease.


ABSTRACT:

SUBMITTER: Boyapati RK 

PROVIDER: S-EPMC6494506 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Withdrawal of immunosuppressant or biologic therapy for patients with quiescent Crohn's disease.

Boyapati Ray K RK   Torres Joana J   Palmela Carolina C   Parker Claire E CE   Silverberg Orli M OM   Upadhyaya Sonam D SD   Nguyen Tran M TM   Colombel Jean-Frédéric JF  

The Cochrane database of systematic reviews 20180512


<h4>Background</h4>Crohn's disease (CD) is a chronic, relapsing and remitting disease of the gastrointestinal tract that can cause significant morbidity and disability. Current treatment guidelines recommend early intervention with immunosuppressant or biological therapy in high-risk patients with a severe disease phenotype at presentation. The feasibility of therapeutic de-escalation once remission is achieved is a commonly encountered question in clinical practice, driven by patient and clinic  ...[more]

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2018-02-01 | GSE107865 | GEO