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Genotypic and Phenotypic Characterization of Clinical Escherichia coli Sequence Type 405 Carrying IncN2 Plasmid Harboring bla NDM-1.

ABSTRACT: We report a bla NDM-carrying ST405 Escherichia coli recovered from the abdominal fluid of a patient in Shandong, China. This strain belonged to the high-risk phylogenetic group D and carried the virulence genes, papG II, papG III, papC, and iroN. In addition to bla NDM-1, this isolate carried the quinolone resistance gene acc(6')-Ib and extended-spectrum ?-lactamase (ESBL) genes bla CTX-M-15 and bla CTX-M-14. bla NDM-1 was located on a 41 Kb IncN2 self-transmissible plasmid. The IncN2 plasmid named as pJN24NDM1 was fully sequenced and analyzed. Genome comparative analysis showed that IncN2 plasmids harboring carbapenem-resistance genes possessed conserved backbones and variable accessory regions. Phylogenetic analysis of 87 IncN plasmids based on orthologous genes indicated that 9 IncN2 plasmids fell into one phylogenetic clade, while 4 IncN3 plasmids were in two phylogenetic clades of the 74 IncN1 plasmids. The presence of IncN2 plasmids harboring bla NDM in the high-risk clone ST405 E. coli raises serious concerns for its potential of dissemination.

SUBMITTER: Hao Y 

PROVIDER: S-EPMC6499153 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Genotypic and Phenotypic Characterization of Clinical <i>Escherichia coli</i> Sequence Type 405 Carrying IncN2 Plasmid Harboring <i>bla</i> <sub>NDM-1</sub>.

Hao Yingying Y   Shao Chunhong C   Geng Xu X   Bai Yuanyuan Y   Jin Yan Y   Lu Zhiming Z  

Frontiers in microbiology 20190412

We report a <i>bla</i> <sub>NDM</sub>-carrying ST405 <i>Escherichia coli</i> recovered from the abdominal fluid of a patient in Shandong, China. This strain belonged to the high-risk phylogenetic group D and carried the virulence genes, <i>papG II, papG III, papC</i>, and iroN. In addition to <i>bla</i> <sub>NDM-1</sub>, this isolate carried the quinolone resistance gene <i>acc(6')-Ib</i> and extended-spectrum β-lactamase (ESBL) genes <i>bla</i> <sub>CTX-M-15</sub> and <i>bla</i> <sub>CTX-M-14</  ...[more]

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