Ontology highlight
ABSTRACT:
SUBMITTER: Pitchiaya S
PROVIDER: S-EPMC6499680 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Pitchiaya Sethuramasundaram S Mourao Marcio D A MDA Jalihal Ameya P AP Xiao Lanbo L Jiang Xia X Chinnaiyan Arul M AM Schnell Santiago S Walter Nils G NG
Molecular cell 20190402 3
Cellular RNAs often colocalize with cytoplasmic, membrane-less ribonucleoprotein (RNP) granules enriched for RNA-processing enzymes, termed processing bodies (PBs). Here we track the dynamic localization of individual miRNAs, mRNAs, and long non-coding RNAs (lncRNAs) to PBs using intracellular single-molecule fluorescence microscopy. We find that unused miRNAs stably bind to PBs, whereas functional miRNAs, repressed mRNAs, and lncRNAs both transiently and stably localize within either the core o ...[more]