Ontology highlight
ABSTRACT:
SUBMITTER: Mazloomian A
PROVIDER: S-EPMC6499833 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Mazloomian Alborz A Araki Shinsuke S Ohori Momoko M El-Naggar Amal M AM Yap Damian D Bashashati Ali A Nakao Shoichi S Sorensen Poul H PH Nakanishi Atsushi A Shah Sohrab S Aparicio Samuel S
Communications biology 20190503
The RNA helicase EIF4A3 regulates the exon junction complex and nonsense-mediated mRNA decay functions in RNA transcript processing. However, a transcriptome-wide network definition of these functions has been lacking, in part due to the lack of suitable pharmacological inhibitors. Here we employ short-duration graded EIF4A3 inhibition using small molecule allosteric inhibitors to define the transcriptome-wide dependencies of EIF4A3. We thus define conserved cellular functions, such as cell cycl ...[more]