Association between IL-1R2 polymorphisms and lung cancer risk in the Chinese Han population: A case-control study.

ABSTRACT:

Background

Interleukin-1 receptor 2 (IL-1R2), as an anti-inflammatory cytokine, is involved in the pathogenesis and progression of lung cancer. However, the role of IL-1R2 polymorphisms in patients with lung cancer has yet to be fully elucidated.

Methods

Six single-nucleotide polymorphisms (SNPs) in IL-1R2 were genotyped in 259 patients and 346 healthy controls. We used the chi-squared test, genetic model analysis, Haploview analysis, and multifactor dimensionality reduction (MDR) to evaluate the potential association between IL-1R2 polymorphisms and lung cancer susceptibility. Bioinformatics analyses were conducted to analyze the expression level of IL-1R2 and its association with the overall survival of lung cancer.

Results

Our results found that rs3218977-GG was as

SUBMITTER: Wang C 

PROVIDER: S-EPMC6503014 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature