Ontology highlight
ABSTRACT:
SUBMITTER: Sanchez CP
PROVIDER: S-EPMC6506540 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Sanchez Cecilia P CP Karathanasis Christos C Sanchez Rodrigo R Cyrklaff Marek M Jäger Julia J Buchholz Bernd B Schwarz Ulrich S US Heilemann Mike M Lanzer Michael M
Communications biology 20190508
PfEMP1 (erythrocyte membrane protein 1) adhesins play a pivotal role in the pathophysiology of falciparum malaria, by mediating sequestration of <i>Plasmodium falciparum</i>-infected erythrocytes in the microvasculature. PfEMP1 variants are expressed by <i>var</i> genes and are presented on membrane elevations, termed knobs. However, the organization of PfEMP1 on knobs is largely unclear. Here, we use super-resolution microscopy and genetically altered parasites expressing a modified <i>var2cs</ ...[more]