Ontology highlight
ABSTRACT:
SUBMITTER: Leimbacher PA
PROVIDER: S-EPMC6509287 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Leimbacher Pia-Amata PA Jones Samuel E SE Shorrocks Ann-Marie K AK de Marco Zompit Mara M Day Matthew M Blaauwendraad Jordy J Bundschuh Diana D Bonham Sarah S Fischer Roman R Fink Daniel D Kessler Benedikt M BM Oliver Antony W AW Pearl Laurence H LH Blackford Andrew N AN Stucki Manuel M
Molecular cell 20190318 3
In mitosis, cells inactivate DNA double-strand break (DSB) repair pathways to preserve genome stability. However, some early signaling events still occur, such as recruitment of the scaffold protein MDC1 to phosphorylated histone H2AX at DSBs. Yet, it remains unclear whether these events are important for maintaining genome stability during mitosis. Here, we identify a highly conserved protein-interaction surface in MDC1 that is phosphorylated by CK2 and recognized by the DNA-damage response med ...[more]