Ontology highlight
ABSTRACT:
SUBMITTER: Blackford AN
PROVIDER: S-EPMC4374139 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Molecular cell 20150301 6
The Bloom syndrome helicase BLM and topoisomerase-IIβ-binding protein 1 (TopBP1) are key regulators of genome stability. It was recently proposed that BLM phosphorylation on Ser338 mediates its interaction with TopBP1, to protect BLM from ubiquitylation and degradation (Wang et al., 2013). Here, we show that the BLM-TopBP1 interaction does not involve Ser338 but instead requires BLM phosphorylation on Ser304. Furthermore, we establish that disrupting this interaction does not markedly affect BLM ...[more]