Ontology highlight
ABSTRACT:
SUBMITTER: Sullivan MR
PROVIDER: S-EPMC6510537 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Sullivan Mark R MR Danai Laura V LV Lewis Caroline A CA Chan Sze Ham SH Gui Dan Y DY Kunchok Tenzin T Dennstedt Emily A EA Vander Heiden Matthew G MG Muir Alexander A
eLife 20190416
Cancer cell metabolism is heavily influenced by microenvironmental factors, including nutrient availability. Therefore, knowledge of microenvironmental nutrient levels is essential to understand tumor metabolism. To measure the extracellular nutrient levels available to tumors, we utilized quantitative metabolomics methods to measure the absolute concentrations of >118 metabolites in plasma and tumor interstitial fluid, the extracellular fluid that perfuses tumors. Comparison of nutrient levels ...[more]