Ontology highlight
ABSTRACT:
SUBMITTER: Oakley AJ
PROVIDER: S-EPMC6511741 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Protein science : a publication of the Protein Society 20190417 6
DNA replication mechanisms are conserved across all organisms. The proteins required to initiate, coordinate, and complete the replication process are best characterized in model organisms such as Escherichia coli. These include nucleotide triphosphate-driven nanomachines such as the DNA-unwinding helicase DnaB and the clamp loader complex that loads DNA-clamps onto primer-template junctions. DNA-clamps are required for the processivity of the DNA polymerase III core, a heterotrimer of α, ε, and ...[more]