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Mechanical forces rewire metabolism in the tumor niche.

ABSTRACT: Tumor niche extracellular matrix stiffening and tumor cell metabolic reprogramming are two fundamental mediators of tumor progression. We recently elucidated a mechanistic interconnection between mechanotransduction and tumor metabolic rewiring in cancer. We demonstrated a stiffness-dependent amino acid crosstalk between stromal and cancer cells that fuels tumor progression and metastatic spreading.

SUBMITTER: Bertero T

PROVIDER: S-EPMC6512933 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Mechanical forces rewire metabolism in the tumor niche.

Bertero Thomas T Gaggioli Cedric C

Molecular & cellular oncology 20190325 3

Tumor niche extracellular matrix stiffening and tumor cell metabolic reprogramming are two fundamental mediators of tumor progression. We recently elucidated a mechanistic interconnection between mechanotransduction and tumor metabolic rewiring in cancer. We demonstrated a stiffness-dependent amino acid crosstalk between stromal and cancer cells that fuels tumor progression and metastatic spreading. ...[more]

PMID: 31131310

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