Ontology highlight
ABSTRACT:
SUBMITTER: Xie AJ
PROVIDER: S-EPMC6516177 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Aging cell 20190227 3
Tauopathies are a class of neurodegenerative diseases that are characterized by pathological aggregation of tau protein, which is accompanied by synaptic disorders. However, the role of tau in endocytosis, a fundamental process in synaptic transmission, remains elusive. Here, we report that forced expression of human tau (hTau) in mouse cortical neurons impairs endocytosis by decreasing the level of the GTPase dynamin 1 via disruption of the miR-132-MeCP2 pathway; this process can also be detect ...[more]