MiR-132/212 deficiency impairs tau metabolism and promotes pathological aggregation in vivo.
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ABSTRACT:
SUBMITTER: Smith PY
PROVIDER: S-EPMC4634376 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Publications
miR-132/212 deficiency impairs tau metabolism and promotes pathological aggregation in vivo.
Smith Pascal Y PY Hernandez-Rapp Julia J Jolivette Francis F Lecours Cynthia C Bisht Kanchan K Goupil Claudia C Dorval Veronique V Parsi Sepideh S Morin Françoise F Planel Emmanuel E Bennett David A DA Fernandez-Gomez Francisco-Jose FJ Sergeant Nicolas N Buée Luc L Tremblay Marie-Ève MÈ Calon Frédéric F Hébert Sébastien S SS
Human molecular genetics 20150911 23
Alzheimer's disease (AD) and related tauopathies comprise a large group of neurodegenerative diseases associated with the pathological aggregation of tau protein. While much effort has focused on understanding the function of tau, little is known about the endogenous mechanisms regulating tau metabolism in vivo and how these contribute to disease. Previously, we have shown that the microRNA (miRNA) cluster miR-132/212 is downregulated in tauopathies such as AD. Here, we report that miR-132/212 d ...[more]
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