Ontology highlight
ABSTRACT:
SUBMITTER: Glober NK
PROVIDER: S-EPMC6521570 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Glober Nancy K NK Sprague Shane S Ahmad Sadiya S Mayfield Katherine G KG Fletcher Lauren M LM Digicaylioglu Murat H MH Sayre Naomi L NL
Neuroscience journal 20190502
After traumatic brain injury (TBI), multiple ongoing processes contribute to worsening and spreading of the primary injury to create a secondary injury. One major process involves disrupted fluid regulation to create vascular and cytotoxic edema in the affected area. Although understanding of factors that influence edema is incomplete, the astrocyte water channel Aquaporin 4 (AQP4) has been identified as an important mediator and therefore attractive drug target for edema prevention. The FDA-app ...[more]