Ontology highlight
ABSTRACT:
SUBMITTER: Silva DA
PROVIDER: S-EPMC6521699 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Nature 20190109 7738
We describe a de novo computational approach for designing proteins that recapitulate the binding sites of natural cytokines, but are otherwise unrelated in topology or amino acid sequence. We use this strategy to design mimics of the central immune cytokine interleukin-2 (IL-2) that bind to the IL-2 receptor βγ<sub>c</sub> heterodimer (IL-2Rβγ<sub>c</sub>) but have no binding site for IL-2Rα (also called CD25) or IL-15Rα (also known as CD215). The designs are hyper-stable, bind human and mouse ...[more]