Drying Enhances Signal Intensities for Global GC?MS Metabolomics.
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ABSTRACT:
SUBMITTER: Liebeke M
PROVIDER: S-EPMC6523563 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Publications
Drying Enhances Signal Intensities for Global GC⁻MS Metabolomics.
Liebeke Manuel M Puskás Erik E
Metabolites 20190405 4
We report here that a straightforward change of the standard derivatization procedure for GC⁻MS metabolomics is leading to a strong increase in metabolite signal intensity. Drying samples between methoxymation and trimethylsilylation significantly increased signals by two- to tenfold in extracts of yeast cells, plant and animal tissue, and human urine. This easy step reduces the cost of sample material and the need for expensive new hardware. ...[more]
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