Ontology highlight
ABSTRACT:
SUBMITTER: Ainsua-Enrich E
PROVIDER: S-EPMC6527354 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Ainsua-Enrich Erola E Hatipoglu Ibrahim I Kadel Sapana S Turner Sean S Paul Jinny J Singh Simar S Bagavant Harini H Kovats Susan S
Mucosal immunology 20190515 4
Acute respiratory disease caused by influenza viruses is imperfectly mitigated by annual vaccination to select strains. Development of vaccines that elicit lung-resident memory CD8<sup>+</sup> T cells (T<sub>RM</sub>) would offer more universal protection to seasonal and emerging pandemic viruses. Understanding how lung-resident dendritic cells (DCs) regulate T<sub>RM</sub> differentiation would be an important step in this process. Here, we used CD11c-cre-Irf4<sup>f/f</sup> (KO) mice, which lac ...[more]