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Monocyte-Derived Dendritic Cells Dictate the Memory Differentiation of CD8+ T Cells During Acute Infection.


ABSTRACT: Monocyte-derived dendritic cells (moDCs) have been shown to robustly expand during infection; however, their roles in anti-infectious immunity remain unclear. Here, we found that moDCs were dramatically increased in the secondary lymphoid organs during acute LCMV infection in an interferon-? (IFN-?)-dependent manner. We also found that priming by moDCs enhanced the differentiation of memory CD8+ T cells compared to differentiation primed by conventional dendritic cells (cDCs) through upregulation of Eomesodermin (Eomes) and T cell factor-1 (TCF-1) expression in CD8+ T cells. Consequently, impaired memory formation of CD8+ T cells in mice that had reduced numbers of moDCs led to defective clearance of pathogens upon rechallenge. Mechanistically, attenuated interleukin-2 (IL-2) signaling in CD8+ T cells primed by moDCs was responsible for the enhanced memory programming of CD8+ T cells. Therefore, our findings unveil a specialization of the antigen-presenting cell subsets in the fate determination of CD8+ T cells during infection and pave the way for the development of a novel therapeutic intervention on infection.

SUBMITTER: Shin KS 

PROVIDER: S-EPMC6706816 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Monocyte-Derived Dendritic Cells Dictate the Memory Differentiation of CD8<sup>+</sup> T Cells During Acute Infection.

Shin Kwang-Soo KS   Jeon Insu I   Kim Byung-Seok BS   Kim Il-Kyu IK   Park Young-Jun YJ   Koh Choong-Hyun CH   Song Boyeong B   Lee Jeong-Mi JM   Lim Jiyoung J   Bae Eun-Ah EA   Seo Hyungseok H   Ban Young Ho YH   Ha Sang-Jun SJ   Kang Chang-Yuil CY  

Frontiers in immunology 20190816


Monocyte-derived dendritic cells (moDCs) have been shown to robustly expand during infection; however, their roles in anti-infectious immunity remain unclear. Here, we found that moDCs were dramatically increased in the secondary lymphoid organs during acute LCMV infection in an interferon-γ (IFN-γ)-dependent manner. We also found that priming by moDCs enhanced the differentiation of memory CD8<sup>+</sup> T cells compared to differentiation primed by conventional dendritic cells (cDCs) through  ...[more]

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