Ontology highlight
ABSTRACT:
SUBMITTER: Shin KS
PROVIDER: S-EPMC6706816 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Shin Kwang-Soo KS Jeon Insu I Kim Byung-Seok BS Kim Il-Kyu IK Park Young-Jun YJ Koh Choong-Hyun CH Song Boyeong B Lee Jeong-Mi JM Lim Jiyoung J Bae Eun-Ah EA Seo Hyungseok H Ban Young Ho YH Ha Sang-Jun SJ Kang Chang-Yuil CY
Frontiers in immunology 20190816
Monocyte-derived dendritic cells (moDCs) have been shown to robustly expand during infection; however, their roles in anti-infectious immunity remain unclear. Here, we found that moDCs were dramatically increased in the secondary lymphoid organs during acute LCMV infection in an interferon-γ (IFN-γ)-dependent manner. We also found that priming by moDCs enhanced the differentiation of memory CD8<sup>+</sup> T cells compared to differentiation primed by conventional dendritic cells (cDCs) through ...[more]