Ontology highlight
ABSTRACT:
SUBMITTER: Wu Q
PROVIDER: S-EPMC6529216 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
eLife 20190423
mRNA translation decodes nucleotide into amino acid sequences. However, translation has also been shown to affect mRNA stability depending on codon composition in model organisms, although universality of this mechanism remains unclear. Here, using three independent approaches to measure exogenous and endogenous mRNA decay, we define which codons are associated with stable or unstable mRNAs in human cells. We demonstrate that the regulatory information affecting mRNA stability is encoded in codo ...[more]