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An Allosteric Switch Primes Sequence-Specific DNA Recognition.

ABSTRACT: Regulation of protein-DNA binding specificity occurs through myriad mechanisms. Boudet et al. discover yet a new form of specificity through allosteric regulation, an ATP-induced structural switch that mediates specific DNA recognition in an archaeoeukaryotic primase.

SUBMITTER: Walker MJ

PROVIDER: S-EPMC6532627 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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An Allosteric Switch Primes Sequence-Specific DNA Recognition.

Walker Matthew J MJ Varani Gabriele G

Cell 20190101 1-2

Regulation of protein-DNA binding specificity occurs through myriad mechanisms. Boudet et al. discover yet a new form of specificity through allosteric regulation, an ATP-induced structural switch that mediates specific DNA recognition in an archaeoeukaryotic primase. ...[more]

PMID: 30633906

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