Ontology highlight
ABSTRACT:
SUBMITTER: Sun R
PROVIDER: S-EPMC6533205 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Sun Ruifen R Gong Jianyu J Li Ju J Ruan Zhiguo Z Yang Xiaomi X Zheng Yongren Y Qing Lili L He Xiaoshan X Jiang Jike J Peng Yanxia Y Zou Haijian H
Bioscience reports 20190523 5
Growing evidence has demonstrated that single-nucleotide polymorphisms (SNPs) in the promoter of miRNA may influence individuals' susceptibility to human diseases. We examined two SNPs rs10877887 and rs13293512 in the promoters of let-7 family to determine if the two SNPs were related to the occurrence of breast cancer (BC). Genotyping of the two SNPs was performed by PCR and restriction fragment length polymorphism analysis or TaqMan assay in 301 BC patients and 310 age matched controls. We fou ...[more]