Ontology highlight
ABSTRACT:
SUBMITTER: Hishinuma T
PROVIDER: S-EPMC6535569 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Antimicrobial agents and chemotherapy 20190524 6
A novel VIM-type metallo-β-lactamase variant, VIM-60, was identified in multidrug-resistant <i>Pseudomonas aeruginosa</i> clinical isolates in Japan. Compared with VIM-2, VIM-60 had two amino acid substitutions (Arg228Leu and His252Arg) and higher catalytic activities against fourth-generation cephalosporins. The genetic context for <i>bla</i><sub>VIM-60</sub> was <i>intI1-bla</i><sub>VIM-60</sub>-<i>aadA1-aacA31-qacEdeltaI-sulI</i> on the chromosome. ...[more]