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VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany.

ABSTRACT: Two Pseudomonas aeruginosa urine isolates from Bulgaria and Germany produced two new VIM-2 variants. VIM-15 had one amino acid substitution (Tyr218Phe) which caused a significant increase in hydrolytic efficiency. The substitution Ser54Leu, characterizing VIM-16, showed no influence on enzyme activity. Both genes were part of class I integrons located in the chromosome.

SUBMITTER: Schneider I

PROVIDER: S-EPMC2493107 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature

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VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany.

Schneider Ines I Keuleyan Emma E Rasshofer Rudolf R Markovska Rumyana R Queenan Anne Marie AM Bauernfeind Adolf A

Antimicrobial agents and chemotherapy 20080602 8

Two Pseudomonas aeruginosa urine isolates from Bulgaria and Germany produced two new VIM-2 variants. VIM-15 had one amino acid substitution (Tyr218Phe) which caused a significant increase in hydrolytic efficiency. The substitution Ser54Leu, characterizing VIM-16, showed no influence on enzyme activity. Both genes were part of class I integrons located in the chromosome. ...[more]

PMID: 18519714

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