Ontology highlight
ABSTRACT:
SUBMITTER: Ivanova E
PROVIDER: S-EPMC6538333 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Ivanova Elena E Alam Nazia M NM Prusky Glen T GT Sagdullaev Botir T BT
JCI insight 20190319
Changes in neuronal activity alter blood flow to match energy demand with the supply of oxygen and nutrients. This functional hyperemia is maintained by interactions between neurons, vascular cells, and glia. However, how changing neuronal activity prevalent at the onset of neurodegenerative disease affects neurovascular elements is unclear. Here, in mice with photoreceptor degeneration, a model of neuron-specific dysfunction, we combined assessment of visual function, neurovascular unit structu ...[more]