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Effects of GSM and UMTS mobile telephony signals on neuron degeneration and blood-brain barrier permeation in the rat brain.

ABSTRACT: Blood-brain barrier (BBB) permeation and neuron degeneration were assessed in the rat brain following exposure to mobile communication radiofrequency (RF) signals (GSM-1800 and UMTS-1950). Two protocols were used: (i) single 2?h exposure, with rats sacrificed immediately, and 1?h, 1, 7, or 50 days later, and (ii) repeated exposures (2?h/day, 5 days/week, for 4 weeks) with the effects assessed immediately and 50 days after the end of exposure. The rats' heads were exposed at brain-averaged specific absorption rates (BASAR) of 0.026, 0.26, 2.6, and 13?W/kg. No adverse impact in terms of BBB leakage or neuron degeneration was observed after single exposures or immediately after the end of repeated exposure, with the exception of a transient BBB leakage (UMTS, 0.26?W/kg). Fifty days after repeated exposure, the occurrence of degenerating neurons was unchanged on average. However, a significant increased albumin leakage was detected with both RF signals at 13?W/kg. In this work, the strongest, delayed effect was induced by GSM-1800 at 13?W/kg. Considering that 13?W/kg BASAR in the rat head is equivalent to 4 times as much in the human head, deleterious effects may occur following repeated human brain exposure above 50?W/kg.

SUBMITTER: Poulletier de Gannes F

PROVIDER: S-EPMC5686211 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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Effects of GSM and UMTS mobile telephony signals on neuron degeneration and blood-brain barrier permeation in the rat brain.

Poulletier de Gannes Florence F Masuda Hiroshi H Billaudel Bernard B Poque-Haro Emmanuelle E Hurtier Annabelle A Lévêque Philippe P Ruffié Gilles G Taxile Murielle M Veyret Bernard B Lagroye Isabelle I

Scientific reports 20171114 1

Blood-brain barrier (BBB) permeation and neuron degeneration were assessed in the rat brain following exposure to mobile communication radiofrequency (RF) signals (GSM-1800 and UMTS-1950). Two protocols were used: (i) single 2 h exposure, with rats sacrificed immediately, and 1 h, 1, 7, or 50 days later, and (ii) repeated exposures (2 h/day, 5 days/week, for 4 weeks) with the effects assessed immediately and 50 days after the end of exposure. The rats' heads were exposed at brain-averaged specif ...[more]

PMID: 29138435

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Dataset Information

Effects of GSM and UMTS mobile telephony signals on neuron degeneration and blood-brain barrier permeation in the rat brain.

Publications

Effects of GSM and UMTS mobile telephony signals on neuron degeneration and blood-brain barrier permeation in the rat brain.

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