Ontology highlight
ABSTRACT:
SUBMITTER: Geng L
PROVIDER: S-EPMC6538594 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Protein & cell 20180801 6
Aging increases the risk of various diseases. The main goal of aging research is to find therapies that attenuate aging and alleviate aging-related diseases. In this study, we screened a natural product library for geroprotective compounds using Werner syndrome (WS) human mesenchymal stem cells (hMSCs), a premature aging model that we recently established. Ten candidate compounds were identified and quercetin was investigated in detail due to its leading effects. Mechanistic studies revealed tha ...[more]