Ontology highlight
ABSTRACT:
SUBMITTER: Lagerweij T
PROVIDER: S-EPMC5094961 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Lagerweij Tonny T Hiddingh Lotte L Biesmans Dennis D Crommentuijn Matheus H W MH Cloos Jacqueline J Li Xiao-Nan XN Kogiso Mari M Tannous Bakhos A BA Vandertop W Peter WP Noske David P DP Kaspers Gertjan J L GJ Würdinger Tom T Hulleman Esther E
Oncotarget 20160601 24
Treatment of medulloblastoma in children fails in approximately 30% of patients, and is often accompanied by severe late sequelae. Therefore, more effective drugs are needed that spare normal tissue and diminish long-term side effects. Since radiotherapy plays a pivotal role in the treatment of medulloblastoma, we set out to identify novel drugs that could potentiate the effect of ionizing radiation.Thereto, a small molecule library, consisting of 960 chemical compounds, was screened for its abi ...[more]