Probing transient non-native states in amyloid beta fiber elongation by NMR.
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ABSTRACT:
SUBMITTER: Brender JR
PROVIDER: S-EPMC6544147 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Publications
Probing transient non-native states in amyloid beta fiber elongation by NMR.
Brender Jeffrey R JR Ghosh Anirban A Kotler Samuel A SA Krishnamoorthy Janarthanan J Bera Swapna S Morris Vanessa V Sil Timir Baran TB Garai Kanchan K Reif Bernd B Bhunia Anirban A Ramamoorthy Ayyalusamy A
Chemical communications (Cambridge, England) 20190401 31
Using NMR to probe transient binding of Aβ1-40 monomers to fibers, we find partially bound conformations with the highest degree of interaction near F19-K28 and a lesser degree of interaction near the C-terminus (L34-G37). This represents a shift away from the KLVFFA recognition sequence (residues 16-21) currently used for inhibitor design. ...[more]
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