Ontology highlight
ABSTRACT:
SUBMITTER: Santofimia-Castano P
PROVIDER: S-EPMC6546470 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Santofimia-Castaño Patricia P Xia Yi Y Lan Wenjun W Zhou Zhengwei Z Huang Can C Peng Ling L Soubeyran Philippe P Velázquez-Campoy Adrián A Abián Olga O Rizzuti Bruno B Neira José L JL Iovanna Juan J
The Journal of clinical investigation 20190328 6
Intrinsically disordered proteins (IDPs) are emerging as attractive drug targets by virtue of their prevalence in various diseases including cancer. Drug development targeting IDPs is challenging because they have dynamical structure features and conventional drug design is not applicable. NUPR1 is an IDP playing an important role in pancreatic cancer. We previously reported that Trifluoperazine (TFP), an antipsychotic agent, was capable of binding to NUPR1 and inhibiting tumors growth. Unfortun ...[more]