Ontology highlight
ABSTRACT:
SUBMITTER: Gao G
PROVIDER: S-EPMC6547413 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Gao Guozhen G Zhang Liang L Villarreal Oscar D OD He Wei W Su Dan D Bedford Ella E Moh Phoebe P Shen Jianjun J Shi Xiaobing X Bedford Mark T MT Xu Han H
Nucleic acids research 20190601 10
PRMT5 is an arginine methyltransferase that accounts for the vast majority of the symmetric methylation in cells. PRMT5 exerts its function when complexed with MEP50/WDR77. This activity is often elevated in cancer cells and correlates with poor prognosis, making PRMT5 a therapeutic target. To investigate the PRMT5 signaling pathway and to identify genes whose loss-of-function sensitizes cancer cells to PRMT5 inhibition, we performed a CRISPR/Cas9 genetic screen in the presence of a PRMT5 inhibi ...[more]