Ontology highlight
ABSTRACT:
SUBMITTER: Basnayake K
PROVIDER: S-EPMC6548358 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Basnayake Kanishka K Mazaud David D Bemelmans Alexis A Rouach Nathalie N Korkotian Eduard E Holcman David D
PLoS biology 20190604 6
Fast calcium transients (<10 ms) remain difficult to analyse in cellular microdomains, yet they can modulate key cellular events such as trafficking, local ATP production by endoplasmic reticulum-mitochondria complex (ER-mitochondria complex), or spontaneous activity in astrocytes. In dendritic spines receiving synaptic inputs, we show here that in the presence of a spine apparatus (SA), which is an extension of the smooth ER, a calcium-induced calcium release (CICR) is triggered at the base of ...[more]