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Tau Positron Emission Tomography Binding Is Not Elevated in HIV-Infected Individuals.


ABSTRACT: Regional standardized uptake value ratios (SUVRs) for tau positron emission tomography (PET) were compared among 19 cognitively normal human immunodeficiency virus (HIV)-negative control individuals, 20 HIV-negative patients with symptomatic Alzheimer disease, 15 cognitively normal HIV-positive individuals, and 17 cognitively impaired HIV-positive individuals. Among the HIV-positive participants, the correlation between tau PET SUVRs and both HIV loads and CD4+ T-cell counts (recent and nadir). Tau PET SUVRs were similar for HIV-positive individuals and HIV-negative control individuals. Individuals with symptomatic Alzheimer disease had elevated tau PET SUVRs. Tau PET SUVRs did not correlate with impairment or clinical markers in HIV-positive participants. Older HIV-positive individuals are not at increased risk of tau-mediated neurodegeneration.

SUBMITTER: Cooley SA 

PROVIDER: S-EPMC6548892 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Tau Positron Emission Tomography Binding Is Not Elevated in HIV-Infected Individuals.

Cooley Sarah A SA   Strain Jeremy F JF   Beaumont Helen H   Boerwinkle Anna H AH   Doyle John J   Morris John C JC   Benzinger Tammie L TL   Ances Beau M BM  

The Journal of infectious diseases 20190601 1


Regional standardized uptake value ratios (SUVRs) for tau positron emission tomography (PET) were compared among 19 cognitively normal human immunodeficiency virus (HIV)-negative control individuals, 20 HIV-negative patients with symptomatic Alzheimer disease, 15 cognitively normal HIV-positive individuals, and 17 cognitively impaired HIV-positive individuals. Among the HIV-positive participants, the correlation between tau PET SUVRs and both HIV loads and CD4+ T-cell counts (recent and nadir).  ...[more]

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