Ontology highlight
ABSTRACT:
SUBMITTER: Salvage SC
PROVIDER: S-EPMC6550012 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Salvage Samantha C SC Gallant Esther M EM Beard Nicole A NA Ahmad Shiraz S Valli Haseeb H Fraser James A JA Huang Christopher L-H CL Dulhunty Angela F AF
Journal of cell science 20190521 10
Mutations in the cardiac ryanodine receptor Ca<sup>2+</sup> release channel (RyR2) can cause deadly ventricular arrhythmias and atrial fibrillation (AF). The RyR2-P2328S mutation produces catecholaminergic polymorphic ventricular tachycardia (CPVT) and AF in hearts from homozygous RyR2<sup>P2328S/P2328S</sup> (denoted RyR2<sup>S/S</sup>) mice. We have now examined P2328S RyR2 channels from RyR2<sup>S/S</sup> hearts. The activity of wild-type (WT) and P2328S RyR2 channels was similar at a cytopla ...[more]