Dataset Information

Subliminal emotional pictures are capable of modulating early cerebral responses to pain in fibromyalgia.

ABSTRACT: Pain experience involves a complex relationship between sensory and both emotional and cognitive factors, which appear to be mediated by different neural pathways. Previous evidence has shown that whereas conscious processing of unpleasant stimuli enhances pain perception, the influence of emotions on pain under unaware conditions is much less known. The need to better characterise the relationship between pain processing and emotional factors is crucial for dealing with chronic pain conditions. Therefore, the present study aimed to explore the neural correlates relating to the influence of visual masking emotional stimulation on the processing of painful stimuli in chronic pain patients suffering from fibromyalgia (FM). Twenty FM and 22 healthy control (HC) women participated in the study. The experimental masking paradigm consisted of a rapid succession of two types of stimuli, where a masked picture (neutral, negative or pain-related) was followed by a laser stimulus (painful or not painful). LEP activity was recorded at sixty scalp electrodes. An LEP-amplitude approach was used to quantify the main cerebral waves linked to pain response. ANOVAs indicated that the posterior regions of the P1 component were sensitive to experimental manipulation (p<0.05). Specifically, FM patients showed higher amplitudes to painful stimuli preceded by pain-related pictures compared with painful trials preceded by other emotional pictures. The FM group also showed greater amplitudes than those in the HC group in P2a and P2b waves. In addition to the scalp data, at the neural level the posterior cingulate cortex, lingual gyrus and insular cortex showed higher activation in the FM group than in the HC group. Our findings show an early cerebral modulation of pain (as reflected by the P1) in FM patients, suggesting that only pain-related information, even when it is unconsciously perceived, is capable to enhance exogenous (automatic) attention, increasing the neural activity involved in processing painful stimulation. Further research is needed to fully understand unconscious emotional influences on pain in fibromyalgia.

SUBMITTER: Pelaez I

PROVIDER: S-EPMC6550399 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Subliminal emotional pictures are capable of modulating early cerebral responses to pain in fibromyalgia.

Peláez Irene I Ferrera David D Barjola Paloma P Fernandes Roberto R Mercado Francisco F

PloS one 20190605 6

Pain experience involves a complex relationship between sensory and both emotional and cognitive factors, which appear to be mediated by different neural pathways. Previous evidence has shown that whereas conscious processing of unpleasant stimuli enhances pain perception, the influence of emotions on pain under unaware conditions is much less known. The need to better characterise the relationship between pain processing and emotional factors is crucial for dealing with chronic pain conditions. ...[more]

PMID: 31166997

Similar Datasets

Project description:In daily life, our emotions are often elicited by a multimodal environment, mainly visual and auditory stimuli. Therefore, it is crucial to investigate the symmetrical characteristics of emotional responses to pictures and sounds. In this study, we aimed to elucidate the relationship of attentional states to emotional unimodal stimuli (pictures or sounds) and emotional responses by measuring the pupil diameter, which reflects the emotional arousal associated with increased sympathetic activity. Our hypothesis was that the emotional responses to both the image and sound stimuli are symmetrical: emotion might be suppressed when attentional resources are allocated to another stimulus of the same modality as the emotional stimulus-such as a dot presented at the same time as an emotional image, and a beep sound presented at the same time as an emotional sound. In our two experiments, data for 24 participants were analyzed for a pupillary response. In experiment 1, we investigated the relationship of the attentional state with emotional visual stimuli (International Affective Picture System) and emotional responses by using pupillometry. We set four task conditions to modulate the attentional state (emotional task, no task, visual detection task, and auditory detection task). We observed that the velocity of pupillary dilation was faster during the presentation of emotionally arousing pictures compared to that of neutral ones, regardless of the valence of the pictures. Importantly, this effect was not dependent on the task condition. In experiment 2, we investigated the relationship of the attentional state with emotional auditory sounds (International Affective Digitized Sounds) and emotional responses. We observed a trend towards a significant interaction between the stimulus and the task conditions with regard to the velocity of pupillary dilation. In the emotional and auditory detection tasks, the velocity of pupillary dilation was faster with positive and neutral sounds than negative sounds. However, there were no significant differences between the no task and visual detection task conditions. Taken together, the current data reveal that different pupillary responses were elicited to emotional visual and auditory stimuli, at least in the point that there is no attentional effect to emotional responses to visual stimuli, despite both experiments being sufficiently controlled to be of symmetrical experimental design.

Project description:BackgroundDysregulation of the μ-opioid receptor has been reported in fibromyalgia (FM) and was linked to pain severity. Here, we investigated the effect of the functional genetic polymorphism of the μ-opioid receptor gene (OPRM1) (rs1799971) on symptom severity, pain sensitivity and cerebral pain processing in FM subjects and healthy controls (HC).MethodsSymptom severity and pressure pain sensitivity was assessed in FM subjects (n = 70) and HC (n = 35). Cerebral pain-related activation was assessed by functional magnetic resonance imaging during individually calibrated painful pressure stimuli.ResultsFibromyalgia subjects were more pain sensitive but no significant differences in pain sensitivity or pain ratings were observed between OPRM1 genotypes. A significant difference was found in cerebral pain processing, with carriers of at least one G-allele showing increased activation in posterior cingulate cortex (PCC) extending to precentral gyrus, compared to AA homozygotes. This effect was significant in FM subjects but not in healthy participants, however, between-group comparisons did not yield significant results. Seed-based functional connectivity analysis was performed with the seed based on differences in PCC/precentral gyrus activation between OPRM1 genotypes during evoked pain across groups. G-allele carriers displayed decreased functional connectivity between PCC/precentral gyrus and prefrontal cortex.ConclusionsG-allele carriers showed increased activation in PCC/precentral gyrus but decreased functional connectivity with the frontal control network during pressure stimulation, suggesting different pain modulatory processes between OPRM1 genotypes involving altered fronto-parietal network involvement. Furthermore, our results suggest that the overall effects of the OPRM1 G-allele may be driven by FM subjects.SignificanceWe show that the functional polymorphism of the μ-opioid receptor gene OPRM1 was associated with alterations in the fronto-parietal network as well as with increased activation of posterior cingulum during evoked pain in FM. Thus, the OPRM1 polymorphism affects cerebral processing in brain regions implicated in salience, attention, and the default mode network. This finding is discussed in the light of pain and the opioid system, providing further evidence for a functional role of OPRM1 in cerebral pain processing.

Project description:From an evolutionary perspective, environmental threats relevant for survival constantly challenged human beings. Current research suggests the evolution of a fear processing module in the brain to cope with these threats. Recently, humans increasingly encountered modern threats (e.g., guns or car accidents) in addition to evolutionary threats (e.g., snakes or predators) which presumably required an adaptation of perception and behavior. However, the neural processes underlying the perception of these different threats remain to be elucidated. We investigated the effect of image content (i.e., evolutionary vs. modern threats) on the activation of neural networks of emotion processing. During functional magnetic resonance imaging (fMRI) 41 participants watched affective pictures displaying evolutionary-threatening, modern-threatening, evolutionary-neutral and modern-neutral content. Evolutionary-threatening stimuli evoked stronger activations than modern-threatening stimuli in left inferior frontal gyrus and thalamus, right middle frontal gyrus and parietal regions as well as bilaterally in parietal regions, fusiform gyrus and bilateral amygdala. We observed the opposite effect, i.e., higher activity for modern-threatening than for evolutionary-threatening stimuli, bilaterally in the posterior cingulate and the parahippocampal gyrus. We found no differences in subjective arousal ratings between the two threatening conditions. On the valence scale though, subjects rated modern-threatening pictures significantly more negative than evolutionary-threatening pictures, indicating a higher level of perceived threat. The majority of previous studies show a positive relationship between arousal rating and amygdala activity. However, comparing fMRI results with behavioral findings we provide evidence that neural activity in fear processing areas is not only driven by arousal or valence, but presumably also by the evolutionary content of the stimulus. This has also fundamental methodological implications, in the sense to suggest a more elaborate classification of stimulus content to improve the validity of experimental designs.

Dataset Information

Subliminal emotional pictures are capable of modulating early cerebral responses to pain in fibromyalgia.

Publications

Subliminal emotional pictures are capable of modulating early cerebral responses to pain in fibromyalgia.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets