Mitochondrial dysfunction and its role in tissue-specific cellular stress.
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ABSTRACT:
SUBMITTER: Pacheu-Grau D
PROVIDER: S-EPMC6551628 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Publications
Mitochondrial dysfunction and its role in tissue-specific cellular stress.
Pacheu-Grau David D Rucktäschel Robert R Deckers Markus M
Cell stress 20180713 8
Mitochondrial bioenergetics require the coordination of two different and independent genomes. Mutations in either genome will affect mitochondrial functionality and produce different sources of cellular stress. Depending on the kind of defect and stress, different tissues and organs will be affected, leading to diverse pathological conditions. There is no curative therapy for mitochondrial diseases, nevertheless, there are strategies described that fight the various stress forms caused by the m ...[more]
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