Ontology highlight
ABSTRACT:
SUBMITTER: Lin SL
PROVIDER: S-EPMC2840080 | biostudies-other | 2010 Mar
REPOSITORIES: biostudies-other
Lin Shuei-Liong SL Li Bing B Rao Sujata S Yeo Eun-Jin EJ Hudson Thomas E TE Nowlin Brian T BT Pei Huaying H Chen Lijun L Zheng Jie J JJ Carroll Thomas J TJ Pollard Jeffrey W JW McMahon Andrew P AP Lang Richard A RA Duffield Jeremy S JS
Proceedings of the National Academy of Sciences of the United States of America 20100216 9
Macrophages are required for tissue homeostasis through their role in regulation of the immune response and the resolution of injury. Here we show, using the kidney as a model, that the Wnt pathway ligand Wnt7b is produced by macrophages to stimulate repair and regeneration. When macrophages are inducibly ablated from the injured kidney, the canonical Wnt pathway response in kidney epithelial cells is reduced. Furthermore, when Wnt7b is somatically deleted in macrophages, repair of injury is gre ...[more]