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Use of quantitative T2 mapping for the assessment of renal cell carcinomas: first results.

ABSTRACT: BACKGROUND:Correct staging and grading of patients with clear cell renal cell carcinoma (cRCC) is of clinical relevance for the prediction of operability and for individualized patient management. As partial or radial resection with postoperative tumor grading currently remain the methods of choice for the classification of cRCC, non-invasive preoperative alternatives to differentiate lower grade from higher grade cRCC would be beneficial. METHODS:This institutional-review-board approved cross-sectional study included twenty-seven patients (8 women, mean age?±?SD, 61.3?±?14.2) with histopathologically confirmed cRCC, graded according to the International Society of Urological Pathology (ISUP). A native, balanced steady-state free precession T2 mapping sequence (TrueFISP) was performed at 1.5?T. Quantitative T2 values were measured with circular 2D ROIs in the solid tumor portion and also in the normal renal parenchyma (cortex and medulla). To estimate the optimal cut-off T2 value for identifying lower grade cRCC, a Receiver Operating Characteristic Curve (ROC) analysis was performed and sensitivity and specificity were calculated. Students' t-tests were used to evaluate the differences in mean values for continuous variables, while intergroup differences were tested for significance with two-tailed Mann-Whitney-U tests. RESULTS:There were significant differences between the T2 values for lower grade (ISUP 1-2) and higher grade (ISUP 3-4) cRCC (p

SUBMITTER: Adams LC

PROVIDER: S-EPMC6555952 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Use of quantitative T2 mapping for the assessment of renal cell carcinomas: first results.

Adams Lisa C LC Bressem Keno K KK Jurmeister Phillipp P Fahlenkamp Ute L UL Ralla Bernhard B Engel Guenther G Hamm Bernd B Busch Jonas J Makowski Marcus R MR

Cancer imaging : the official publication of the International Cancer Imaging Society 20190607 1

<h4>Background</h4>Correct staging and grading of patients with clear cell renal cell carcinoma (cRCC) is of clinical relevance for the prediction of operability and for individualized patient management. As partial or radial resection with postoperative tumor grading currently remain the methods of choice for the classification of cRCC, non-invasive preoperative alternatives to differentiate lower grade from higher grade cRCC would be beneficial.<h4>Methods</h4>This institutional-review-board a ...[more]

PMID: 31174616

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Project description:BACKGROUND:Long acquisition times and motion sensitivity limit T2 mapping in the abdomen. Accelerated mapping at 3 T may allow for quantitative assessment of diffuse pancreatic disease in patients during free-breathing. PURPOSE:To test the feasibility of respiratory-triggered quantitative T2 analysis in the pancreas and correlate T2 -values with age, body mass index, pancreatic location, main pancreatic duct dilatation, and underlying pathology. STUDY TYPE:Retrospective single-center pilot study. POPULATION:Eighty-eight adults. FIELD STRENGTH/SEQUENCE:Ten-fold accelerated multiecho-spin-echo 3 T MRI sequence to quantify T2 at 3 T. ASSESSMENT:Two radiologists independently delineated three regions of interest inside the pancreatic head, body, and tail for each acquisition. Means and standard deviations for T2 values in these regions were determined. T2 -value variation with demographic data, intraparenchymal location, pancreatic duct dilation, and underlying pancreatic disease was assessed. STATISTICAL TESTS:Interreader reliability was determined by calculating the interclass coefficient (ICCs). T2 values were compared for different pancreatic locations by analysis of variance (ANOVA). Interpatient associations between T2 values and demographical, clinical, and radiological data were calculated (ANOVA). RESULTS:The accelerated T2 mapping sequence was successfully performed in all participants (mean acquisition time, 2:48 ± 0:43 min). Low T2 value variability was observed across all patients (intersubject) (head: 60.2 ± 8.3 msec, body: 63.9 ± 11.5 msec, tail: 66.8 ± 16.4 msec). Interreader agreement was good (ICC, 0.82, 95% confidence interval: 0.77-0.86). T2 -values differed significantly depending on age (P < 0.001), location (P < 0.001), main pancreatic duct dilatation (P < 0.001), and diffuse pancreatic disease (P < 0.03). DATA CONCLUSION:The feasibility of accelerated T2 mapping at 3 T in moving abdominal organs was demonstrated in the pancreas, since T2 values were stable and reproducible. In the pancreatic parenchyma, T2 -values were significantly dependent on demographic and clinical parameters. LEVEL OF EVIDENCE:4 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2019;50:410-416.

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Use of quantitative T2 mapping for the assessment of renal cell carcinomas: first results.

Publications

Use of quantitative T2 mapping for the assessment of renal cell carcinomas: first results.

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