Ontology highlight
ABSTRACT:
SUBMITTER: Gupta AS
PROVIDER: S-EPMC6557670 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Gupta Angela S AS Waters Michael R MR Biswas Debolina D DD Brown Lashardai N LN Surace Michael J MJ Floros Constantinos C Siebenlist Ulrich U Kordula Tomasz T
Glia 20190407 8
In response to brain injury or infections, astrocytes become reactive, undergo striking morphological and functional changes, and secrete and respond to a spectrum of inflammatory mediators. We asked whether reactive astrocytes also display adaptive responses during sterile IL-1β-induced neuroinflammation, which may limit tissue injury associated with many disorders of the central nervous system. We found that astrocytes display days-to-weeks long specific tolerance of cytokine genes, which is c ...[more]