Ontology highlight
ABSTRACT:
SUBMITTER: Chen YL
PROVIDER: S-EPMC7062525 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20200301 3
Plasmacytoid dendritic cells (pDCs) produce type I interferon (IFN-I) and are traditionally defined as being BDCA-2+CD123+. pDCs are not readily detectable in healthy human skin, but have been suggested to accumulate in wounds. Here, we describe a CD1a-bearing BDCA-2+CD123int DC subset that rapidly infiltrates human skin wounds and comprises a major DC population. Using single-cell RNA sequencing, we show that these cells are largely activated DCs acquiring features compatible with lymph node ho ...[more]