Ontology highlight
ABSTRACT:
SUBMITTER: Yang L
PROVIDER: S-EPMC6560278 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Yang Lu L Ravikanthachari Nitin N Mariño-Pérez Ricardo R Deshmukh Riddhi R Wu Mariana M Rosenstein Adam A Kunte Krushnamegh K Song Hojun H Andolfatto Peter P
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20190603 1777
The repeated evolutionary specialization of distantly related insects to cardenolide-containing host plants provides a stunning example of parallel adaptation. Hundreds of herbivorous insect species have independently evolved insensitivity to cardenolides, which are potent inhibitors of the alpha-subunit of Na<sup>+</sup>,K<sup>+</sup>-ATPase (ATPα). Previous studies investigating ATPα-mediated cardenolide insensitivity in five insect orders have revealed remarkably high levels of parallelism in ...[more]