Ontology highlight
ABSTRACT:
SUBMITTER: Meyer NL
PROVIDER: S-EPMC6561701 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Meyer Nancy L NL Hu Guiqing G Davulcu Omar O Xie Qing Q Noble Alex J AJ Yoshioka Craig C Gingerich Drew S DS Trzynka Andrew A David Larry L Stagg Scott M SM Chapman Michael Stewart MS
eLife 20190522
Adeno-associated virus (AAV) vectors are preeminent in emerging clinical gene therapies. Generalizing beyond the most tractable genetic diseases will require modulation of cell specificity and immune neutralization. Interactions of AAV with its cellular receptor, AAVR, are key to understanding cell-entry and trafficking with the rigor needed to engineer tissue-specific vectors. <i>Cryo</i>-electron tomography shows ordered binding of part of the flexible receptor to the viral surface, with dista ...[more]