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Cytotoxic, Anti-Migration, and Anti-Invasion Activities on Breast Cancer Cells of Angucycline Glycosides Isolated from a Marine-Derived Streptomyces sp.

ABSTRACT: Four angucycline glycosides were previously characterized from marine-derived Streptomyces sp. OC1610.4. Further investigation of this strain cultured on different fermentation media from that used previously resulted in the isolation of two new angucycline glycosides, vineomycins E and F (1-2), and five known homologues, grincamycin L (3), vineomycinone B2 (4), fridamycin D (5), moromycin B (7), and saquayamycin B1 (8). Vineomycin F (2) contains an unusual ring-cleavage deoxy sugar. All the angucycline glycosides isolated from Streptomyces sp. OC1610.4 were evaluated for their cytotoxic activity against breast cancer cells MCF-7, MDA-MB-231, and BT-474. Moromycin B (7), saquayamycin B1 (8), and saquayamycin B (9) displayed potent anti-proliferation against the tested cell lines, with IC50 values ranging from 0.16 to 0.67 ?M. Saquayamycin B (9) inhibited the migration and invasion of MDA-MB-231 cells in a dose-dependent manner, as detected by Transwell and wound-healing assays.

SUBMITTER: Qu XY 

PROVIDER: S-EPMC6562490 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Cytotoxic, Anti-Migration, and Anti-Invasion Activities on Breast Cancer Cells of Angucycline Glycosides Isolated from a Marine-Derived <i>Streptomyces</i> sp.

Qu Xin-Ying XY   Ren Jin-Wei JW   Peng Ai-Hong AH   Lin Shi-Qi SQ   Lu Dan-Dan DD   Du Qian-Qian QQ   Liu Ling L   Li Xia X   Li Er-Wei EW   Xie Wei-Dong WD  

Marine drugs 20190509 5

Four angucycline glycosides were previously characterized from marine-derived <i>Streptomyces</i> sp. OC1610.4. Further investigation of this strain cultured on different fermentation media from that used previously resulted in the isolation of two new angucycline glycosides, vineomycins E and F (<b>1</b>-<b>2</b>), and five known homologues, grincamycin L (<b>3</b>), vineomycinone B<sub>2</sub> (<b>4</b>), fridamycin D (<b>5</b>), moromycin B (<b>7</b>), and saquayamycin B<sub>1</sub> (<b>8</b>  ...[more]

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