Ontology highlight
ABSTRACT:
SUBMITTER: Xu X
PROVIDER: S-EPMC6563025 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Xu Xiaoxiao X Liang Jiazhen J Zhang Zheyu Z Jiang Tao T Yu Rilei R
Marine drugs 20190523 5
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that are involved in fast synaptic transmission and mediated physiological activities in the nervous system. α-Conotoxin ImI exhibits subtype-specific blockade towards homomeric α7 and α9 receptors. In this study, we established a method to build a 2×ImI-dendrimer/h (human) α7 nAChR model, and based on this model, we systematically investigated the molecular interactions between the 2×ImI-dendrimer and hα7 nAChR. Our result ...[more]