Ontology highlight
ABSTRACT:
SUBMITTER: Lerchner W
PROVIDER: S-EPMC6563815 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Lerchner W W Corgiat B B Der Minassian V V Saunders R C RC Richmond B J BJ
Gene therapy 20140109 3
We, like many others, wish to use modern molecular methods to alter neuronal functionality in primates. For us, this requires expression in a large proportion of the targeted cell population. Long generation times make germline modification of limited use. The size and intricate primate brain anatomy poses additional challenges. We surved methods using lentiviruses and serotypes of adeno-associated viruses (AAVs) to introduce active molecular material into cortical and subcortical regions of old ...[more]