No differential gene expression for CD4⁺ T cells of MS patients and healthy controls.

ABSTRACT:

Background

Multiple sclerosis-associated genetic variants indicate that the adaptive immune system plays an important role in the risk of developing multiple sclerosis. It is currently not well understood how these multiple sclerosis-associated genetic variants contribute to multiple sclerosis risk. CD4⁺ T cells are suggested to be involved in multiple sclerosis disease processes.

Objective

We aim to identify CD4⁺ T cell differential gene expression between multiple sclerosis patients and healthy controls in order to understand better the role of these cells in multiple sclerosis.

Methods

We applied RNA sequencing on CD4⁺ T cells from multiple sclerosis patients and healthy controls.

Results

We did not identify significantly dif

SUBMITTER: Brorson IS 

PROVIDER: S-EPMC6566490 | biostudies-literature | 2019 Apr-Jun

REPOSITORIES: biostudies-literature