Ontology highlight
ABSTRACT:
SUBMITTER: Li Z
PROVIDER: S-EPMC6568190 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Li Ziduo Z Ju Xinsheng X Silveira Pablo A PA Abadir Edward E Hsu Wei-Hsun WH Hart Derek N J DNJ Clark Georgina J GJ
Frontiers in immunology 20190607
CD83 is a member of the immunoglobulin (Ig) superfamily and is expressed in membrane bound or soluble forms. Membrane CD83 (mCD83) can be detected on a variety of activated immune cells, although it is most highly and stably expressed by mature dendritic cells (DC). mCD83 regulates maturation, activation and homeostasis. Soluble CD83 (sCD83), which is elevated in the serum of patients with autoimmune disease and some hematological malignancies is reported to have an immune suppressive function. ...[more]