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Characterizing the Neuroprotective Effects of S/B Remedy (Scutellaria baicalensis Georgi and Bupleurum scorzonerifolfium Willd) in Spinal Cord Injury.


ABSTRACT: The main causes of dysfunction after a spinal cord injury (SCI) include primary and secondary injuries that occur during the first minutes, hours, to days after injury. This treatable secondary cascade provides a window of opportunity for delivering therapeutic interventions. An S/B remedy (Scutellaria baicalensis Georgi and Bupleurum scorzonerifolfium Willd) has anti-inflammatory, cytoprotective, and anticarcinogenic effects in liver or neurodegenerative diseases. The present work examined the effect of S/B on injured spinal cord neurons in cultures and in vivo. S/B effectively reduced peroxide toxicity and lipopolysaccharide stimulation in both spinal cord neuron/glial and microglial cultures with the involvement of PKC and HSP70. The effect of S/B was further conducted in contusive SCI rats. Intraperitoneal injections of S/B to SCI rats preserved spinal cord tissues and effectively attenuated microglial activation. Consistently, S/B treatment significantly improved hindlimb functions of SCI rats. In the acute stage of injury, S/B treatment markedly reduced the levels of ED1 expression and lactate and had a tendency to decrease lipid peroxidation. Taken together, we demonstrated long-term hindlimb restoration alongside histological improvements with systemic S/B remedy treatment in a clinically relevant model of contusive SCI. Our findings highlight the potential of an S/B remedy for acute therapeutic intervention after SCI.

SUBMITTER: Tu TH 

PROVIDER: S-EPMC6571778 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Characterizing the Neuroprotective Effects of S/B Remedy (<i>Scutellaria baicalensis</i> Georgi and <i>Bupleurum scorzonerifolfium</i> Willd) in Spinal Cord Injury.

Tu Tsung-Hsi TH   Liou Dann-Ying DY   Lin Di-You DY   Yang Hsin-Chun HC   Chen Ching-Jung CJ   Huang Ming-Chao MC   Huang Wen-Cheng WC   Tsai May-Jywan MJ   Cheng Henrich H  

Molecules (Basel, Switzerland) 20190516 10


The main causes of dysfunction after a spinal cord injury (SCI) include primary and secondary injuries that occur during the first minutes, hours, to days after injury. This treatable secondary cascade provides a window of opportunity for delivering therapeutic interventions. An S/B remedy (<i>Scutellaria baicalensis</i> Georgi and <i>Bupleurum scorzonerifolfium</i> Willd) has anti-inflammatory, cytoprotective, and anticarcinogenic effects in liver or neurodegenerative diseases. The present work  ...[more]

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