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Identification of two nervous system-specific members of the erg potassium channel gene family.

ABSTRACT: Two new potassium channel genes, erg2 and erg3, that are expressed in the nervous system of the rat were identified. These two genes form a small gene family with the previously described erg1 (HERG) gene. The erg2 and erg3 genes are expressed exclusively in the nervous system, in marked contrast to erg1, which is expressed in both neural and non-neural tissues. All three genes are expressed in peripheral sympathetic ganglia. The erg3 channel produces a current that has a large transient component at positive potentials, whereas the other two channels are slowly activating delayed rectifiers. Expression of the erg1 gene in the sympathetic nervous system has potential implications for the etiology of the LQT2 form of the human genetic disease long QT syndrome.

SUBMITTER: Shi W

PROVIDER: S-EPMC6573403 | biostudies-literature | 1997 Dec

REPOSITORIES: biostudies-literature

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Identification of two nervous system-specific members of the erg potassium channel gene family.

Shi W W Wymore R S RS Wang H S HS Pan Z Z Cohen I S IS McKinnon D D Dixon J E JE

The Journal of neuroscience : the official journal of the Society for Neuroscience 19971201 24

Two new potassium channel genes, erg2 and erg3, that are expressed in the nervous system of the rat were identified. These two genes form a small gene family with the previously described erg1 (HERG) gene. The erg2 and erg3 genes are expressed exclusively in the nervous system, in marked contrast to erg1, which is expressed in both neural and non-neural tissues. All three genes are expressed in peripheral sympathetic ganglia. The erg3 channel produces a current that has a large transient compone ...[more]

PMID: 9390998

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